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Coronavirus Biology and Pathogenesis
On the Front Lines
Approaches to Vaccines and Drug Development
Blocking SARS Virus Fusion
Lessons in Interventions for SARS
Status of Drug Screening vs. SARS
Adenovirus Vector Technologies for Vaccines
Some Approaches to Vaccine Development
Panel 3 Discussion
Future Perspectives on Emerging Infections
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SARS in the Context of Emerging Infectious Threats SARS in the Context of Emerging Infectious Threats
Approaches to Vaccines and Drug Development
Adenovirus Vector Technologies for Vaccines

C. Richter King, Genvac Inc., Gaithersburg, VA
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Highlights

Advantages of Adenovirus Vectors
• Can serve as a vaccine platform for several types of disease.
• Trigger strong and potentially medically significant immune response via a variety of different cellular pathways.
• Are well tested in clinic, and are well-tolerated as a vector system and vaccine system.
• Methods to bring AdVectors into the clinic are well established, and manufacturing and quality control procedures are in place.
• Used as an immunization boost in animals, immune response increases greatly, measured by antibody titer and cell-mediated response.
• High numbers of homologous vector can be produced and purified quickly.

Manipulating AdVectors
• All AdVectors are missing essential genes, so they can no longer replicate, making them relatively safe, and freeing space for addition of many expression cassettes.
• Vectors can be optimized for performance and can be used to quickly test many conformations of antigen or multiple antigens.
• DNA can be flexibly moved around using homologous recombination.
• Libraries of genes or various modifications of a single gene can be used to produce a library of AdVectors for testing.
• Broadening the tropism of AdVector can improve antigen presentation by almost an order of magnitude and improved cellular response to antigen.

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